Zіnaida Mosіichuk was born in the village of Kalinovka, Makarovsky district of the Kyiv region (now a town in the Vinnytsia region) in a family of collective farm workers. As a child, the artist survived two years of occupation; in the autobiography, she noted that none of the family members worked with the German authorities; according to her own estimation, she knew German "weakly". In the period from 1946 to 1951, Mosіichuk studied at the Kyiv School of Applied Arts, received education as an artist-executant of architectural and artistic ceramics. After the studies, the artist worked at the Horodnytsia Porcelain Factory, initially as a sculptor, then as a porcelain painter. Three years after her marriage, in 1957, Mosіichuk moved to Baranivka and continued to work as an artist at the Baranivka Porcelain Factory. She visited the Kyiv Experimental Porcelain Factory several times to familiarize with the technique of painting on porcelain. In 1966 her family changed the place of residence again — the artist, her husband and their two children settled in Zhytomyr. The next year Mosіichuk began work at Zhytomyr Art and Production Workshops. The artist applied her porcelain painting experience to the creation of decorative and thematic compositions, in particular, in the field of political poster and interior design. Mosіichuk also developed an innovative technique for using polyester varnishes in decorative paintings. The artist was deeply interested in folk art: she worked in the traditions of Petrykivka painting and was the Chairman of the Commission for work with amateur and folk artists in the Zhytomyr organization of the Union of Artists of Ukraine.